| Start |
End |
Title / Topic |
| 2:00pm |
2:10pm |
Welcome |
- Jennifer Webster-Cyriaque, DDS, PhD, National Institute of Dental and Craniofacial Research Acting Director
|
01 |
| 2:10pm |
3:30pm |
AHEAD Program Overview and Progress |
| 2:10pm |
2:20pm |
Overview of AHEAD Program and AHEAD-EDRN Collaborations |
- Zhong Chen, MD, PhD, National Institute of Dental and Craniofacial Research
- Wendy Wang, PhD, National Cancer Institute
|
02 |
| 2:20pm |
3:30pm |
Discuss Program Milestones, Progress from Years 1-2, and Plans for Year 3 (10 minutes for each group) |
| 2:20pm |
2:30pm |
Mapping Immuno-genomic Drivers of the Head and Neck Precancer Invasive-disease Transition |
- Ludmil Alexandrov, PhD
- Silvio Gutkind, PhD
- Scott Lippman, MD, University of California San Diego
|
03 |
| 2:30pm |
2:40pm |
Advancing On-Slide and Optical Biopsy Tools to Detect High-Risk Oral Premalignancy |
- Yu Leo Lei, DDS, PhD, University of Texas MD Anderson Cancer Center
- Steven Chinn, MD, University of Pittsburgh
- Thomas Wang, PhD, University of Michigan
|
04 |
| 2:40pm |
2:50pm |
Immune and transcriptomic biomarkers of progressive oral premalignant lesions |
- Fatemeh Momen Heravi, DDS, MPH, PhD, University of California San Francisco
|
05 |
| 2:50pm |
3:00pm |
Oral Dysplasia to Carcinomas: Multi-omics Study of Progression |
- Laura Rozek, PhD, Georgetown University
- Maureen Sartor, PhD, University of Michigan
- Nisha D’Silva, BDS, MSD, PhD, University of Michigan
|
06 |
| 3:00pm |
3:10pm |
Early Detection and Risk of Head and Neck Cancer through Immune Based Spatial Omics |
- Sara Pai, MD, PhD, Yale University
|
07 |
| 3:10pm |
3:20pm |
Biomarker Approach to Screening for the early detection of HPV-related Oropharyngeal Cancer (BASH OPC) Study |
- Antonio Amelio, PhD, H. Lee Moffitt Cancer Center
- Anna Giuliano, PhD, H. Lee Moffitt Cancer Center
|
08 |
| 3:20pm |
3:30pm |
R56DE033344: Combined Imaging and RNA Analyses to Predict Head and Neck Cancer Recurrence |
- Hua Li, PhD, Washington University
- Xiaowei Wang, PhD, University of Illinois Chicago
|
09 |
| 3:30pm |
3:40pm |
BREAK |
| 3:40pm |
4:20pm |
Working Group Session #1: Creating a Tumor Bank/ Virtual Library of oral potentially malignant disorders (OPMD) (Discussion lead: Leo Lei)
- Discuss Options and Decide on Platform(s) to Store Images
- Each Site provides an update on the number of OPMD cases identified or to be used in their studies so we can anticipate storage needs
- Create pathology working group representing 2-3 institutions to review the images and categorize the lesions
- Target Goals/Deliverables
- PIs of AHEAD to download images – Timeline 12-18 months with completion by Year 4 of funding period
- Pathology working group to categorize lesions - Timeline 12 months with completion by Year 4 of funding period
- Share OPMD Virtual Library with the rest of the AHEAD group in Year 4 as a validation set
|
|
| 4:20pm |
5:00pm |
Working Group Session #2: Spatial Transcriptomics Analyses/Programs (Discussion lead: Fatemeh Momen Heravi)
- Each group shares the platforms from their spatial transcriptomics datasets and results thus far
- Discuss various spatial transcriptomics platforms being used
- Target Goals/Deliverables
- Group generates high priority markers to be tested in validation sets across the AHEAD program
|
|
| 5:00pm |
5:45pm |
Identification of Next Steps for AHEAD and AHEAD-EDRN Collaboration
- Funding Opportunities for Collaborations: EDRN Core Fund and Associate Membership Program (Guillermo Marquez, NCI)
Moderators: AHEAD Co-Chairs
- Harmonization of oral rinse or gargle samples across sites
- Validating identified murine markers in human scRNASeq datasets of OPMD
|
|
| 5:45pm |
5:55pm |
Summary: ADVANCING HEAD & NECK CANCER EARLY DETECTION RESEARCH (AHEAD) |
Sara Pai, MD, PhD, Yale University |
10 |
| 5:55pm |
6:00pm |
Closing Remarks |
Sudhir Srivastava, PhD, MPH, Senior Scientific Officer & Chief, National Cancer Institute |
11 |
| 6:00pm |
|
ADJOURN |
|