EDRN Gastrointestinal (GI) Collaborative Group Meeting Agenda EDRN Gastrointestinal (GI) Collaborative Group Meeting Wednesday, September 17, 2025, 9:00 a.m. – 1:00 p.m. PT Location: Eastlake E3-160 Chair: Robert Bresalier, MD, University of Texas MD Anderson Cancer Center Co-Chair: Cecilia Yeung, MD, Fred Hutchinson Cancer Center NCI Program Directors: Matt Young, PhD, National Cancer Institute DMCC Staff: Ziding Feng, PhD, Stephanie Page Lester, BS, Fred Hutchinson Cancer Center Wednesday, September 17, 2025 Start End Topic / Institution Presenter Number 9:00am 9:15am NCI Updates Matthew Young, PhD, National Cancer Institute 01 9:15am 9:30am NOD Cohort and Opportunities Ziding Feng, PhD, Fred Hutchinson Cancer Center 02 9:30am 9:35am Q&A 9:35am 1:00pm GI Collaborative Group Presentation 9:35am 10:05am Biomarkers for optimizing risk prediction and early detection of cancers of the colon and esophagus (15 min on topics for NCT, 15 min to update on BDL/BRL) William Grady, MD (BDL) Cecilia Yeung, MD or representative (BRL) 03 10:05am 10:10am Q&A 10:10am 1:00pm CVC Presentations CVC should limit presentation to the listed topics needed for the NCT. A more detailed presentation can be made at the CVC sessions. 10:10am 10:25am Biomarker Based Interception of Esophageal Adenocarcinoma Sanford Markowitz, MD, PhD, Case Western Reserve University Nicholas Shaheen, MD, MPH, University of North Carolina Amitabh Chak, MD, UH Cleveland Medical Center Chetan Bettegowda, MD, PhD, Johns Hopkins University Sachin Wani, MD, University of Colorado Anschutz Medical Campus Edward Willis, MD, Case Western Reserve University 04 10:25am 10:30am Q&A 10:30am 10:45am EDRN Clinical Validation Center on Pancreatic Cancer Gulf Coast-Great Lakes-East Coast (GCGLEC) CVC (U01CA200468) Anirban Maitra, MD, NYU Langone 05 10:45am 10:50am Q&A 10:50am 11:05am Break 11:05am 11:20am Validation of biomarkers for risk prediction and early diagnosis of Pancreatic Adenocarcinoma Randall Brand, MD, University of Pittsburgh Surinder Batra, PhD, University of Nebraska Medical Center 06 11:20am 11:25am Q&A 11:25am 11:40am EDRN Clinical Validation Center on Advanced Adenomas Detection U. Pittsburgh - City of Hope - Hopkins CVC (U01CA271884) Robert Schoen, MD, PhD, University of Pittsburgh Cancer Institute Cristian Tomasetti, PhD, City of Hope/TGen 07 11:40am 11:45am Q&A 11:45am 12:00pm Great Lakes-New England (GLNE) Clinical Validation Center Update Robert Bresalier, MD, The University of Texas MD Anderson Cancer Center Sapna Syngal, MD, MPH, Dana Farber Cancer Institute 08 12:00pm 12:05pm Q&A 12:05pm 12:20pm Liver Clinical Validation Center Amit Singal, MD, The University of Texas Southwestern at Dallas Neehar Parikh, MD, University of Michigan Fasiha Kanwal, MD, Baylor College of Medicine Jorge Marrero, MD, University of Pennsylvania 09 12:20pm 12:25pm Q&A 12:25pm 1:00pm Preparation for NCT Chair will prepare presentation for SC session and 7- minute presentation for NCT at EC session, focus on these items: Accomplishments (all cycles): Tests identified for potential inclusion in NCCN trial networks Validated Phase 3 biomarkers available CLIA assays in development Biomarker tests with assigned CPT codes Ongoing high-value projects advancing toward Phase 3 validation Created resources (reference datasets, image repositories) Collaborations with industry, foundations, and external partners Vision and strategic direction for the next EDRN cycle N/A 1:00pm 1:00pm ADJOURN If you have any questions regarding meeting registration, please contact EDRN DMCC at edrndmcc@fredhutch.org.

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