EDRN Lung & Head/Neck Cancers Collaborative Group Meeting Agenda EDRN Lung & Head/Neck Cancers Collaborative Group Meeting Wednesday, September 17, 2025, 9:00 a.m. – 1:00 p.m. PT Location: Weintraub/Pelton Co-Chairs: Eric Grogan, MD, VUMC; Sara Pai, PhD, Yale University; and Marc Lenburg, PhD, Boston University NCI Program Director: Guillermo Marquez, PhD DMCC: Jackie Dahlgren, Camden Lopez Wednesday, September 17, 2025 Start End Title / Topic Presenter / Institution Number 9:00am 9:10am Welcome Guillermo Marquez, PhD, National Cancer Institute N/A 9:10 – 12:20 p.m. | BCC and CVC Presentations Focus Areas: Accomplishments (all cycles): Tests identified for potential inclusion in NCCN trial networks Validated Phase 3 biomarkers available CLIA assays in development Biomarker tests with assigned CPT codes Ongoing high-value projects advancing toward Phase 3 validation Created resources (reference datasets, image repositories) Collaborations with industry, foundations, and external partners Vision and strategic direction for the next EDRN cycle 9:10am 9:20am Moffitt CVC Matt Schabath, PhD, H. Lee Moffitt Cancer Center and Research Institute, Inc. 01 9:20am 9:30am MDACC CVC Sam Hanash, MD, PhD, The University of Texas MD Anderson Cancer Center 02 9:30am 9:40am Vanderbilt CVC Eric Grogan, MD, Vanderbilt-Ingram Cancer Center Stephen Deppen, PhD, Vanderbilt University Medical Center 03 9:40am 9:50am ASU CVC Erich Sturgis, MD, MPH, Baylor College of Medicine 04 9:50am 10:00am ASU BCC Joshua LaBaer, MD, PhD, Arizona State University 05 10:00am 10:10am BU-UCLA BCC Jennifer Beane-Ebel, PhD, Boston University 06 10:10am 10:20am NYU BCC Leopoldo Segal, MD, MS, NYU Langone Health 07 10:20am 10:30am Pittsburgh-Baltimore Lung Cancer Biomarker Characterization Center James Herman, MD, University of Pittsburgh 08 10:30am 10:40am Move AHEAD for the Earliest Detection of Oral Cancer Yu Leo Lei, DDS, PhD, MD Anderson Cancer Center 09 10:40am 10:50am Break 10:50am 11:20am NCT Overview: Lung Collaborative Group Eric Grogan, MD, Vanderbilt University Medical Center 10 11:20am 11:50pm LTP2 Updates DMCC 11 11:50pm 12:05pm Core Funds Updates Guillermo Marquez, PhD, National Cancer Institute 12 12:05pm 12:15pm JHU CVC David Sidransky, MD, Johns Hopkins University School of Medicine 13 12:15pm 12:30pm The mutagenic forces shaping the genomes of lung cancer in never smokers Ludmil Alexandrov, PhD, University of California, San Diego 14 12:30pm 1:00pm Collaborative Projects 12:30pm 12:45pm Overview of AHEAD and Harmonized Tissue Analysis William Hsu, PhD, University of California Los Angeles Matt Schabath, PhD, H. Lee Moffitt Cancer Center and Research Institute, Inc. Ghulam Rasool, PhD, H. Lee Moffitt Cancer Center and Research Institute, Inc. 15 12:45pm 1:00pm Harmonizing AHEAD tissue analysis Ludmil Alexandrov, PhD, University of California San Diego Fatemeh Momen-Heravi, DDS, PhD, MPH, MS, University of California San Francisco 16 1:00pm 1:00pm ADJOURN If you have any questions regarding meeting registration, please contact EDRN DMCC at edrndmcc@fredhutch.org.

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