14th EDRN Scientific Workshop, May 20-22, 2025
 
The Early Detection Research Network (EDRN) will host its 14th EDRN Scientific Workshop "Unleashing the Power of Collaboration: The Future Is Here" from Tuesday-Thursday, May 20-22, 2025 at the DoubleTree by Hilton Washington DC North/Gaithersburg Hotel (in-person only)
 
 
Meeting Registration, Hotel Rooms and Poster Abstracts
  • Meeting Registration: Registration is mandatory to attend this event. Fill out this registration form at https://forms.office.com/r/GmAcQ64dZP?origin=lprLink to register easily online. Please be complete and accurate when completing this form—especially your email address. The deadline to register is Monday, May 12, 2025.

  • Hotel Rooms: EDRN has a block of sleeping rooms at the DoubleTree by Hilton Washington DC North/Gaithersburg hotel. The rate for all attendees is $276/night plus taxes (Includes breakfast and lunch). The deadline to book your room is May 15, 2025 or until the room block is full.
  • CLOSED "Poster Abstracts/Posterboards: The poster session is on Wednesday, May 21st starting with lightning presentations at 10:00 am EDRN Principal Investigators must present a poster at this event and Early Career Investigators are strongly encouraged to present as are other attendees. CVCs are presenting on their biobanks. Please submit your poster abstract to the EDRN DMCC at edrndmcc@fredhutch.org by Friday, April 18, 2025.
  • Presentations: All presentations must be sent to the DMCC either by email (if under 24MB) at edrndmcc@fredhutch.org or via OneDrive the day before the scheduled presentation. Presenters have been notified via email that they have been granted access to the One Drive folder where presentations can be uploaded. Please use the latest version of PowerPoint. NCI requires that we collect all presentations from EDRN events.


Schedule of Events
(Times of Events are Subject to Change)
 
Agenda
Date Time Location Presenter # Topic
Tuesday,
May 20, 2025		 7:00 am – 7:50 am Room:
Majestic Ballroom Foyer		 N/A Check-in and Breakfast (Breakfast and Lunch are Complimentary for Hotel Guests, $25 per meal for local attendees)
Tuesday,
May 20, 2025		 7:50 am – 8:10 am Room:
Majestic Ballroom

01		 Welcome and Opening Remarks
  • Sudhir Srivastava, PhD, MPH, Senior Scientific Officer & Chief, Cancer Biomarkers Research Group, National Cancer Institute

Planning Committee Chairs:
  • Cecilia Yeung, MD, Fred Hutchinson Cancer Center
  • James Willey, MD, University of Toledo College of Medicine
Tuesday,
May 20, 2025		 8:10 am – 8:25 am Room:
Majestic Ballroom		 02 Keynote Address #1
Presenter: Jennifer Webster-Cyriaque, DDS, PhD, Acting Director, National Institute of Dental and Craniofacial Research
Tuesday,
May 20, 2025		 8:25 am – 8:40 am Room:
Majestic Ballroom		 N/A Keynote Address #2
Suzanne McPeak, Say YES to HOPE
Tuesday,
May 20, 2025		 8:40 am – 10:20 am Room:
Majestic Ballroom		 N/A Session 1: Unraveling the Power of Spatial Genomics and Digital Pathology Toward Biomarker Discovery: Analytical and Clinical Validation and Harmonization? (Jointly by EDRN and PreCancer Atlas Investigators

Chair/Co-chair:
  • Cecilia Yeung, MD, Fred Hutchinson Cancer Center
  • Irene Ghobrial, MD, Dana-Farber Cancer Institute/Harvard Medical School
    8:40 am – 9:00 am   03 Michael Snyder. PhD, Stanford University
    9:00 am – 9:05 am     Q&A

    9:05 am – 9:25 am   04 Emerging Computational Approaches and Applications of Single-Cell Spatial Transcriptomics
Evan Newell, PhD, Professor, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center
    9:25 am – 9:30 am     Q&A

    9:30 am – 9:50 am   05 Ben Hindson, PhD, President and CSO, 10x Genomics
    9:50 am – 9:55 am     Q&A

    9:55 am – 10:15 am   06 Shachi Mittal, PhD, University of Washington
    10:15 am – 10:20 am     Q&A

Tuesday,
May 20, 2025		 10:20 am – 10:50 am   N/A Networking Break
Tuesday,
May 20, 2025		 10:50 am – 12:05 pm Room:
Majestic Ballroom		 N/A Session 2: Demystifying Data Science Applications in Multi-Modal Biomarker Development and Validation

Chair/Co-chair:
  • Jennifer Beane, PhD, Boston University School of Medicine
  • Dan Crichton, MA, NASA Jet Propulsion Laboratory
    10:50 am – 11:10 am   07 Corey W. Arnold, PhD, Vice Chair of Research, Department of Radiological Sciences, University of California, Los Angeles
    11:10 am – 11:15 am     Q&A

    11:15 am – 11:35 am   08 Sensitive and Accurate Reference Based Variant Detection for Biomarker Discovery and Early Detection of Cancers
Lior Pachter, PhD, Bren Professor of Computational Biology, California Institute of Technology
    11:35 am – 11:40 am     Q&A

    11:40 am – 12:00 pm   09 Christina Curtis, PhD, MSc, RZ Cao Professor of Medicine, Genetics and Biomedical Data Science, Stanford University
    12:00 pm – 12:05 pm     Q&A

Tuesday,
May 20, 2025		 12:05 pm – 1:30 pm Rooms:
Knife & Fork Restaurant and Innovation & Imagination Room		 N/A Lunch (Breakfast and Lunch are Complimentary for Hotel Guests, $25 per meal for local attendees)
Tuesday,
May 20, 2025		 1:30 pm – 2:45 pm Room:
Majestic Ballroom		 N/A Session 3: Liquid Biopsy Analytical and Clinical Validation and Harmonization
(Jointly by EDRN BRL and LBC)

Chair/Co-chair:
  • Jeff Tosoian, MD, Vanderbilt University Medical Center
  • Nickolas Papadopoulos, PhD, Johns Hopkins University
    1:30 pm – 1:50 pm   10 Epigenomic MultiCancer Detection Using Machine Learning Identifies Signals Common to Cancers and Unique to Tissue of Tumor Origin
Sam Levy, PhD, Clear Note Health
    1:50 pm – 1:55 pm     Q&A

    1:55 pm – 2:15 pm   11 Rob Scharpf, PhD, Associate Professor, Johns Hopkins University
    2:15 pm – 2:20 pm     Q&A

    2:20 pm – 2:40 pm   12 Chris Douville, PhD, Johns Hopkins University
    2:40 pm – 2:45 pm     Q&A

Tuesday,
May 20, 2025		 2:45 pm – 3:15 pm   N/A Networking Break
Tuesday,
May 20, 2025		 3:15 pm – 4:55 pm Room:
Majestic Ballroom		 N/A Session 4: Unleashing the Power of Imaging and Radiomics

Chair:
Anirban Maitra, MBBS, The University of Texas MD Anderson Cancer Center
    3:15 pm – 3:35 pm   13 Brian Wolpin, MD, MPH, Medical Oncologist, Dana-Farber Cancer Institute
    3:35 pm – 3:40 pm     Q&A

    3:40 pm – 4:00 pm   14 Dana Ataya, MD, Associate Professor, H. Lee Moffitt Cancer Center and Research Institute, Inc.
    4:00 pm – 4:05 pm     Q&A

    4:05 pm – 4:25 pm   15 Fluorescence Lifetime Imaging for Drug Development, Surgical Guidance and Diagnosis
Anand Kumar, PhD, Harvard Medical School
    4:25 pm – 4:30 pm     Q&A

    4:30 pm – 4:50 pm   16 Eric Grogan, MD, Professor of Thoracic Surgery, Vanderbilt University Medical Center
    4:50 pm – 4:55 pm     Q&A

Tuesday,
May 20, 2025		 4:55 pm – 5:25 pm Room:
Majestic Ballroom		 N/A Panel Discussion for Sessions 1-4: Biomarker Development

Chair:
  • David Wong, DMD, DMSC, University of California, Los Angeles


Panelists:
  • Eric Grogan, MD, Professor of Thoracic Surgery, Vanderbilt University Medical Center
  • Ben Hindson, PhD, President and CSO, 10x Genomics
  • Chris Douville, PhD, Johns Hopkins University
  • Corey W. Arnold, PhD, Vice Chair of Research, University of California, Los Angeles
Tuesday,
May 20, 2025		 5:25 pm – 5:55 pm Room:
Majestic Ballroom		 N/A Forum Discussion
  • Chair: Daniel Crichton, MS, Program Manager, NASA Jet Propulsion Laboratory
  • Co-Chair: Jennifer Beane, PhD, Associate Professor, Boston University
  • Panelists:
    • Wendell Jones, PhD, Principal Bioinformaticist and Scientific Advisor at IQVIA Laboratories
    • Anirban Maitra, MBBS, The University of Texas MD Anderson Cancer Center
    • Lior Pachter, PhD, California Institute of Technology
    • Shachi Mittal, PhD, University of Washington
Wednesday,
May 21, 2025		 7:00 am – 8:00 am Room:
Majestic Ballroom Foyer		 N/A Check-in (Breakfast/Lunch is Complimentary for Hotel Guests, $25 per meal for local attendees)
Wednesday,
May 21, 2025		 8:00 am – 8:30 am Room:
Majestic Ballroom		 17 Keynote Address #3
Presenter: Tony Hu, PhD, Weatherhead Presidential Chair in Biotechnology Innovation, Tulane University
Wednesday,
May 21, 2025		 8:30 am – 9:45 am Room:
Majestic Ballroom		 N/A Session 5: Best Practices for Biomarker Discovery and Development

Chair/Co-chair:
  • James Willey, MD, University of Toledo College of Medicine
  • Gerard Davis, PhD, Abbott Laboratories
    8:30 am – 8:50 am   18 Yingye Zheng, PhD, Professor and EDRN Principal Investigator, Fred Hutchinson cancer Center
    8:50 am – 8:55 am     Q&A

    8:55 am – 9:15 am   19 Vickie Petrides, MS, Program Manager, Quality, Abbott Labratories
    9:15 am – 9:20 am     Q&A

    9:20 am – 9:40 am   20 Making Machine Learning and AI Clinically Relevant, Rigorous, and Reproducible for Biomarker Development
Wendell Jones, PhD, Principal Bioinformaticist and Scientific Advisor at IQVIA Laboratories Genomics & Executive Chair of the MAQC Society
    9:40 am – 9:45 am     Q&A

Wednesday,
May 21, 2025		 9:45 am – 10:00 am   N/A Break
Wednesday,
May 21, 2025		 10:00 am – 11:00 am Room:
Majestic Ballroom		 N/A Poster Lightening Presentations (6 presentations)
    10:00 am – 10:05 am   21 Semi-quantitative lateral flow immunoassay (LFA) test to detect autoantibodies for Ovarian Cancer
Karen Anderson, MD, PhD, Arizona State University ty School of Medicine and Advanced Medical Engineering
    10:05 am – 10:10 am     Q&A

    10:10 am – 10:15 am   22 Multiplexed Nanoprobe Assay For PCR-free, RNA Isolation-free and Ultrasensitive Detection of Circulating Transcripts for Early Detection of Pancreatic Cancer & Clinical Validation of A Novel Blood-based Protein Multi-analyte Test for Early Detection of Pancreatic Ductal Adenocarcinoma (PDAC) in A Large High-risk Patient Population
Randy Brand, MD, University of Pittsburgh &
Norma Palma, PhD, Immunovia
    10:15 am – 10:20 am     Q&A

    10:20 am – 10:25 am   23 Mapping Tumor Infiltrating Lymphocytes in Whole Prostatectomy Specimens: A Tile-Based Approach to Visualizing and Quantifying the Immune Microenvironment of Prostate Cancer
Sandra Gaston, PhD, University of Miami Miller School of Medicine
    10:25 am – 10:30 am     Q&A

    10:30 am – 10:35 am   24 Defining Chromosome 3q Amplification as an Early Event in Progression to Squamous Cell Carcinoma of the Head and Neck
Srivivas Saladi, PhD, University of Toledo, College of Medicine and Life Sciences
    10:35 am – 10:40 am     Q&A

    10:40 am – 10:45 am   25 Cancer Associated Macrophage-Like cells are Circulating Stromal Cell Subpopulations that act as a Screening Tool for Invasive Solid Tumors and Prognosticates for Highly Aggressive Cancer Subtypes
Daniel Adams, BS, Creatv Microtech, Inc.
    10:45 am – 10:50 am     Q&A

    10:50 am – 10:55 am   26 Validation of OneTest Premium™ Cancer Risk Test Using Capillary Blood Samples & OneTest™ Premium: Demonstrating early detection of cancer with PLCO samples
Jiming Zhou, PhD, 20/20 BioLab
    10:55 am – 11:00 am     Q&A

    11:00 am – 11:05 am   26.1 Jointly Learning from Radiology-pathology Data to Improve the Discovery of CT Imaging Biomarkers for Lung Cancer Detection
Stephen Park, BS, University of California, Los Angeles
    11:05 am – 11:10 am     Q&A

Wednesday,
May 21, 2025		 11:10 am – 12:30 pm Rooms:
Knife & Fork Restaurant and Innovation & Imagination Room		 N/A Lunch (Breakfast and Lunch are Complimentary for Hotel Guests, $25 per meal for local attendees)
Wednesday,
May 21, 2025		 12:30 pm – 2:00 pm Room:
Discovery Ballroom		 N/A Poster Session
Wednesday,
May 21, 2025		 2:00 pm – 3:00 pm Room:
Majestic Ballroom		 N/A Session 6: Novel Biomarker Discovery Technology and Late Breaking Abstracts: Flash Talks for Selected Abstracts (5-min each) and Consortia (EDRN, PCDC, PCA, TBEL, LB, TLC) ESI Presentations

Chair/Co-chair:
  • Arul Chinnaiyan, MD, PhD, University of Michigan
  • Michael Goggins, MD, Johns Hopkins University
    2:00 pm – 2:15 pm   27 Optofluidic Platform for Time-resolved Label-free Molecular Profiling of Extracellular Vesicles
Pascal Ruedi, PhD, PDepartment of Mechanical and Process Engineering, ETH Zurich
    2:15 pm – 2:20 pm     Q&A

    2:20 pm – 2:35 pm   28
William Grady, MD, Fred Hutchinson Cancer Center
    2:35 pm – 2:40 pm     Q&A

    2:40 pm – 2:55 pm   29 Ashley Kiemen, PhD, Assistant Professor of Pathology, Johns Hopkins
Ashley Kiemen, PhD, Professor, Johns Hopkins
    2:55 pm – 3:00 pm     Q&A

Wednesday,
May 21, 2025		 3:00 pm – 4:30 pm Room:
Majestic Ballroom		 N/A Session 7: Biobanks: Fueling The Multi-Omics Approaches For Biomarker Discovery (Introductions and 3 Presentations)

Chair/Co-chair:
  • Stephen Deppen, PhD, Vanderbilt University Medical Center
  • Randy Brand, MD, University of Pittsburgh
    3:00 pm – 3:10 pm   N/A Introduction
Stephen Deppen, PhD, Associate Professor, Vanderbilt University Medical Center
    3:10 pm – 3:30 pm   30 Nisha D'Silva, PhD, Professor, University of Michigan
    3:30 pm – 3:35 pm     Q&A

    3:35 pm – 3:55 pm   31 Mathias Johansson, PhD, Scientist, Co-lead of Risk Management and Early Detection Team, International Agency for Research on Cancer (IARC)
    3:55 pm – 4:00 pm     Q&A

    4:00 pm – 4:20 pm   32 Randy Brand, MD, Professor of Medicine, University of Pittsburgh
    4:20 pm – 4:25 pm     Q&A

Thursday,
May 22, 2025		 7:00 am – 8:00 am Room:
Majestic Ballroom Foyer		 N/A Check-in and Breakfast (Breakfast is Complimentary for Hotel Guests, $25 per meal for local attendees)
Thursday,
May 22, 2025		 8:00 am – 8:30 am Room:
Majestic Ballroom		 33 Keynote Address #4
Stephen Hahn, MD, Chief Executive Officer, Harbinger Health
Thursday,
May 22, 2025		 8:30 am – 10:10 am Room:
Majestic Ballroom		 N/A Session 8: Clinical Utility Trials: Clinical Utility Assessment with Focus on the Efforts of the Cancer Screening Network, Including Both MCEDs and Single Cancer Biomarkers

Chair:
Bob Bresalier, MD, The University of Texas MD Anderson Cancer Center
    8:30 am – 8:50 am   34 Cancer Screening Research Network
Elyse Leevan, MD, MPH, National Cancer Institute
    8:50 am – 8:55 am     Q&A

    8:55 am – 9:15 am   35 How We Did It
Paul Limburg, MD, MPH, AGAF Exact Sciences
    9:15 am – 9:20 am     Q&A

    9:20 am – 9:40 am   36 Clinical Utility Trials: Novel Approaches to Study Design to Reduce Sample Size and Accelerate Progress
Bree Mitchell, PhD, Senior Director, Early Cancer Detection, Natera
    9:40 am – 9:45 am     Q&A

    9:45 am – 10:05 am   37 Ruth Etzioni, PhD, Professor, Fred Hutchinson Cancer Center
    10:05 am – 10:10 am     Q&A

Thursday,
May 22, 2025		 10:10 am – 11:00 am Room:
Majestic Ballroom		 N/A Panel Discussion Suggestions for Session 8: Regulatory and Reimbursement Considerations
    10:10 am – 10:20 am   N/A Introduction
Jonathan Cohen, PhD, President and CEO, 20/20 Gene

    10:05 am – 10:10 am   N/A Panel Discussion
Chair: Robert Bresalier, MD, The University of Texas MD Anderson Cancer Center
Panelists:
  • Ruth Etzioni, PhD, Professor, Fred Hutchinson Cancer Center
  • Paul Limburg, MD, MPH, AGAF Exact Sciences
  • Bree Mitchell, PhD, Senior Director, Early Cancer Detection, Natera
  • Jonathan Cohen, PhD, President and CEO, 20/20 Gene
Thursday,
May 22, 2025		 11:00 am – 11:10 am Room:
Majestic Ballroom		 N/A Closing and Final Remarks
Sudhir Srivastava, PhD, MPH, PhD, MPH, Senior Scientific Officer & Chief, Cancer Biomarkers Research Group, National Cancer Institute
Thursday,
May 22, 2025		 11:10 am   N/A Adjourn 14th EDRN Scientific Workshop


If you have any questions regarding meeting registration, please contact EDRN DMCC at edrndmcc@fredhutch.org.

 
 
The meeting registration form created by EDRN DMCC at Fred Hutchinson Cancer Research Center ©