About CARET: Eligibility Criteria

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Rationale for Study

Design

• Eligibility Criteria

• Recruitment

• Intervention

• Follow-up

• Data Collection

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Eligibility Criteria

Eligibility criteria for the two CARET exposure populations were as follows:
Asbestos-exposed participants (N = 4,060)
Men who, on entry to the study,
	were aged 45-69* were current smokers or quit within 15 years prior to enrollment* had their first exposure to asbestos on the job at least 15 years prior to enrollment had a chest X-ray positive for changes compatible with asbestos exposure according to International Labour Organization (ILO) criteria; or had been employed in a protocol-defined high-risk trade for at least 5 years, at least 10 years prior to enrollment
Heavy smoker participants (N = 14,254)
Men and women who, on entry to the study,
	were aged 50-69 had a cigarette smoking history of 20 or more pack-years were current smokers or had quit within the previous 6 years
* For the asbestos pilot study there was no smoking eligibility requirement and the age criterion was 45-74 years. Among the asbestos-exposed participants enrolled during the pilot phase (N = 816), 16% were never smokers and 36% were former smokers who had quit more than 15 years prior to enrollment; 10% were between 70 and 74 years of age.