CARET Operational Leadership

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Operational Leadership

Scientific Leadership

Operational Leadership

Chu Chen, M.S., Ph.D., D.A.B.C.C., is a biochemist, molecular biologist and clinical chemist by training and a board-certified Diplomat of the American Board of Clinical Chemistry. Her involvement with CARET began in 1993, when she founded the Public Health Sciences Core Laboratory at the Fred Hutchinson Cancer Research Center, in which capacity she oversaw the analyses of carotenoids and micronutrients for the CARET study. For over two decades since that time, she has received a number of National Institutes of Health awards to support her research, which has focused on the molecular epidemiology of tobacco-related cancers (head and neck, lung) and hormone-related cancers (breast, endometrium, prostate, testes) and on the development of prognostic gene signatures for patients diagnosed with oral squamous cell carcinoma. Several of these studies were based on CARET samples and data. Dr. Chen received her Ph.D. in biochemistry from the University of Washington. (List of publications via PubMed)

Gary Goodman, M.D., M.S., was the Principal Investigator of the Carotene and Retinol Efficacy Trial (CARET) and was primarily responsible for the overall design of the CARET trial with his experience as a clinical investigator in lung cancer clinical trials. He was responsible for the development of methodology to assess participants for side effects and the laboratory serum vitamin assay. As the Principal Investigator of CARET, Dr. Goodman was responsible for the overall direction of the trial. Dr. Goodman holds a joint membership with the Fred Hutchinson Cancer Research Center and the Swedish Cancer Institute. Dr. Goodman received his M.D. and M.S. in Pharmacology from the University of Illinois. (List of publications via PubMed)

Mark Thornquist, Ph.D., is the lead statistician on the Carotene and Retinol Efficacy Trial (CARET) and has been the Director of the CARET Coordinating Center. Dr. Thornquist was responsible for the analytic methods used to design, monitor, and analyze CARET data. Dr. Thornquist is the Director of the Comprehensive Center for the Advancement of Scientific Strategies (COMPASS), a program within the Cancer Prevention Program in the Public Health Sciences Division of the Fred Hutchinson Cancer Research Center that provides full-spectrum operational support for research. Dr. Thornquist received his Ph.D. in Statistics from the University of Wisconsin. (List of publications via PubMed)

Matt Barnett is the CARET Analytic Section Manager of COMPASS. He has served COMPASS in this role for over two decades, and has been a statistician on CARET even longer. Mr. Barnett consults with scientific investigators on study design issues and provides statistical analyses for publications and reports. He works with scientists and staff on study coordination procedures, providing statistical guidance in the design and development of data collection forms, data management procedures, quality control reports, and quality assurance procedures. Mr. Barnett received a Master of Science degree in Biostatistics from the University of Washington.

Becky Harbine is the Project Coordinator for CARET, working closely with investigators in the coordination of their research projects. Ms. Harbine has been with CARET since 1996, working her way up from a Data Technician to Project Coordinator, and now oversees most activities associated with the CARET Biorepository. This includes processing all proposals requesting the use of CARET samples and/or data, Institutional Review Board compliance, communications between investigators, developing policies, assisting in study implementation, development of research materials, and maintaining the integrity of the CARET specimens. Ms. Harbine has extensive historical knowledge of the CARET Study and Biorepository, benefiting better specimen management. Ms. Harbine received a Bachelor of Arts degree from Western Washington University.