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Publications

 • Design

 • Background

 • Primary Results

 
Types of Study


 • Serum/ Plasma Analysis

 • Dietary Studies

 • Genetic Analysis

 • Intervention Effect

 • Prevention Trial Studies

 • Biorepositories

 
Disease


 • Lung Cancer

 • Breast Cancer

 • Colon Cancer

 • Pancreatic Cancer

 • Prostate Cancer

 • Cardiovascular Disease

 • Asbestosis

 • Chronic Obstructive Pulmonary Disease

 

Active Studies

Pilot & Other Unpublished Studies

Publications
Publications may be listed in more than one category.

Design
Key Paper
Thornquist MD, Omenn GS, Goodman GE, Grizzle JE, Rosenstock L, Barnhart S, Anderson GL, Hammar S, Balmes J, Cherniack M, Cone J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr. Statistical design and monitoring of the Carotene and Retinol Efficacy Trial (CARET). Controlled Clin Trials 14:308-324, 1993.
Other Papers
Prentice RL, Omenn GS, Goodman GE, Chu J, Henderson MM, Feigl P, Kleinman GD, Thomas DB, HutchinsonML, LundB, Day RW. Rationale and design of cancer chemoprevention studies in Seattle. JNCI Monograph Series 69:249-258, 1985.

Grizzle J, Omenn GS, Goodman G, Thornquist M, Rosenstock L, Barnhart S, Balmes J, Cherniack M, Cone J, Cullen M, Glass A, Keogh J, Valanis B. Design of the beta-Carotene and Retinol Efficacy Trial (CARET) for chemoprevention of cancer in populations at high risk: heavy smokers and asbestos-exposed workers. In: Pastorino U, Hong WK, eds. Chemoimmuno Prevention of Cancer, New York/Stuttgart: Thieme Medical Publishers 167-176, 1991.

Omenn GS, Goodman G, Thornquist M, Rosenstock L, Barnhart S, Gylys-Colwell I, Metch B, Lund B. The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high risk populations: pilot study with asbestos-exposed workers. Cancer Epidemiol Biomarkers Prev 2:381-387, 1993.

Goodman G, Omenn GS, Thornquist M, Lund B, Metch B, Gylys-Colwell I. The Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in high-risk populations: pilot study with cigarette smokers. Cancer Epidemiol Biomarkers Prev 2:389-396, 1993.

Omenn GS, Goodman GE, Thornquist M, Grizzle J, Rosenstock L, Barnhart S, Balmes J, Cherniack M, Cullen M, Glass A, Keogh J, Meyskens F Jr, Valanis B, Williams J Jr. The b-Carotene and Retinol Efficacy Trial (CARET) for chemoprevention of lung cancer in high-risk populations: smokers and asbestos-exposed workers. Cancer Res 54:2038S-2043S, 1994.

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Background
Key Paper
Omenn GS. A double-blind randomized trial with beta-carotene and retinol in persons at high risk of lung cancer due to occupational asbestos exposures and/or cigarette smoking. Public Health Rev 16:99-125, 1988.
Other Papers
Goodman GE, Omenn GS, Feigl P, Kleinman GD, Lund B, Thomas DB, Henderson MM, Prentice R. Chemoprevention of lung cancer with retinol/beta-carotene. In: Meyskens FL and Prasad KN, eds. Vitamins and Cancer: Human Cancer Prevention by Vitamins and Micronutrients. Clifton, New Jersey: Humana Press. p. 341-350, 1985.

Omenn GS, Goodman GE, Kleinman GD, Rosenstock L, Barnhart S, Feigl P, Thomas DB, Kalman D, Lund B, Prentice RL, Henderson MM. The role of intervention studies in ascertaining the contribution of dietary factors in lung cancer: the Seattle chemoprevention trial of retinoids in asbestos-exposed workers. Ann NY Acad Sci 534:575-583, 1988.

Omenn GS, Goodman GE, Rosenstock L, Barnhart S, Lund B, Thornquist M, Feigl P. Cancer chemoprevention with vitamin A and beta-carotene in populations at high risk for lung cancer. In: Cerutti PA, Nygaard OF, Simic MG, eds. Anticarcinogenesis and Radiation Protection. New York: Plenum Press 279-283, 1988.

Omenn GS, Goodman GE, Thornquist M, Rosenstock L, Barnhart S, Feigl P. Chemoprevention of lung cancer with beta-carotene and retinol in persons at high risk due to asbestos occupational exposures and/or cigarette smoking: a double-blind randomized trial. In: Wehner AP, ed. Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke. Columbus (OH): Batelle Press 121-143, 1989.

Omenn GS. Chemoprevention of occupationally related lung cancer. Washington Public Health 7:35-36, 1989.

Goodman GE, Omenn GS. Lung cancer chemoprevention in heavy cigarette smokers and asbestos-exposed workers. M.D. Anderson Cancer Center: Cancer Bull 43:534-537, 1991.

Omenn GS, Goodman G, Grizzle J, Thornquist M, Rosenstock L, Barnhart S, Anderson G, Balmes J, Cherniack M, Cone J, Cullen M, Glass A, Keogh J, Meyskens F Jr, Valanis B. CARET, the beta-Carotene and Retinol Efficacy Trial to prevent lung cancer in asbestos-exposed workers and in smokers. In: Sluyser M, ed. Asbestos-Related Cancer. England: Simon and Schuster 302-315, 1991. ALSO: Anti-Cancer Drugs 2:79-86, 1991.

Omenn GS, CARET Co-Investigators and staff. CARET, the beta-Carotene and Retinol Efficacy Trial to prevent lung cancer in high risk populations. Public Health Rev 19:205-208, 1991/92.

Goodman GE, Omenn GS, CARET Co-Investigators and staff. Carotene and Retinol Efficacy Trial: lung cancer chemoprevention trial in heavy cigarette smokers and asbestos-exposed workers. In: Newell GR, Hong WK, eds. The Biology and Prevention of Aerodigestive Tract Cancers, New York: Plenum Press 137-140, 1992.

Goodman GE, Omenn GS, CARET Co-Investigators and staff. Carotene and Retinol Efficacy Trial: lung cancer chemoprevention trial in heavy cigarette smokers and asbestos-exposed workers. Adv Exp Med Biol 320:137-140, 1992.

Goodman GE. Chemoprevention of lung cancer. Lung Cancer Res Q 2:6-19, 1992.

Omenn GS, and CARET Co-Investigators. CARET, the beta-Carotene and Retinol Efficacy Trial to prevent lung cancer in asbestos-exposed workers and in smokers. Sourcebook on Asbestos Diseases Butterworth Press Vol. 7 Ch. 10; 219-241, 1993.

Omenn GS. What accounts for the association of vegetables and fruits with lower incidence of cancer and coronary heart disease? Ann Epidemiol 5:333-335, 1995.

Goodman GE. The prevention of primary lung cancer. In: Johnson BE, Johnson DH, eds. Lung Cancer: Current Clinical Oncology Series, New York: Wiley-Liss 41-53, 1995.

Omenn GS. Micronutrients (vitamins, minerals) as preventive agents. In: Stewart BW, McGregor D, Kleihues P, eds. Principles of Chemoprevention. Lyon, France: IARC Scientific Publications No. 139:33-45, 1996.

Goodman GE. Prevention of lung cancer Current Opinion in Oncology 10:122-126, March 1998

Goodman GE. Prevention of lung cancer. Critical Reviews in Oncology/Hematology. 33:187-197, 2000

Goodman GE. Prevention of lung cancer. Thorax 57:994-999, 2002.

Omenn GS. Human Lung Cancer Chemoprevention Strategies: Parker B. Francis Lecture. Chest 125: 123S-127S, 2004.

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Primary Results
Key Papers
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. NEJM 334:1150-1155, 1996.

Omenn G, Goodman G, Thornquist M, Balmes J, Cullen M, Glass A, Keogh J, Meyskens F, Valanis B, Williams J, Barnhart S, Cherniack M, Brodkin C, Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the beta-Carotene and Retinol Efficacy Trial. JNCI 88:1550-9, 1996.

Goodman, GE, Thornquist MD, Balmes J, Cullen MR, Meyskens F, Omenn GS, Valanis B, Williams J. The Beta-Carotene and Retinol Efficacy Trial: Incidence of Lung Cancer and Cardiovascular Disease Mortality During 6-Year Follow-up After Stopping ?-Carotene and Retinol Supplements. Journal of the National Cancer Institute. 96(23):1743-1750, Dec 2004.

Other Papers
Omenn GS. What accounts for the association of vegetables and fruits with lower incidence of cancer and coronary heart disease? Ann Epidemiol 5:333-335, 1995.

Omenn GS, Goodman GE, Thornquist M, Barnhart S, Balmes J, Cherniack M, Cullen M, Glass A, Keogh J, Liu D, Meyskens F, Perloff M, Valanis B, Williams J. Chemoprevention of lung cancer: the b-Carotene and Retinol Efficacy Trial (CARET) in high-risk smokers and asbestos-exposed workers. In: Hakama M, Beral V, Buiatti E, Faivre J, Parkin DM, eds. Chemoprevention in Cancer Control. Lyon, France: IARC Scientific Publications No.136, 1996.

Omenn G. Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial - Response (Letter). JNCI 89:325-326, February 19, 1997.

Omenn G, Thornquist M. Beta-carotene and the risk of lung cancer - Response (Letter). JNCI 89:457-458, March 19, 1997.

Omenn G, CARET co-authors. Response to Leo MA, Lieber CS letter to the editor: Risk factors for lung cancer and intervention effects in CARET. JNCI 89:1722-1723, November 19, 1997.

Omenn GS, Beresford SAA, Motulsky AG. Preventing coronary heart disease: B vitamins and homocysteine. Circulation 97:421-424, February 1998

Goodman G, Valanis B, Meyskens F, Williams J, Metch B, Thornquist M, Omenn G. Strategies for recruitment to a population-based lung cancer prevention trial: the CARET experience with heavy smokers. Cancer Epidemiology, Biomarkers & Prevention 7:405-412, 1998

Omenn G. Chemoprevention of lung cancer: the rise and demise of beta-carotene. Ann Public Health 19:73-99, 1998.

Bowen DJ, Thornquist M, Anderson K, Barnett M, Powell C, Goodman G, Omenn G Stopping the active intervention: CARET. Controlled Clinical Trials. 24:39-50, 2003.

Omenn GS. Chemoprevention of lung cancers: lessons from CARET, the beta-carotene and retinol efficacy trial, and prospects for the future. Eur J Cancer Prev 16(3):184-91, Jun 2007.

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Serum/Plasma Analysis
Key Papers
Omenn GS, Goodman GE, Thornquist M, Brunzell JD. Long term vitamin A does not produce clinically significant hypertriglyceridemia: results from CARET, the b-Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev 3:711-713, 1994.

Redlich C, Chung JS, Berglund L, Blaner WS, VanBennekum AM, Ramakrishnan R, Cullen MR. Effect of long term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 143(2):427-434, 1999.

Other Papers
Kalman DA, Goodman GE, Omenn GS, Bellamy G, Rollins B. Micronutrient assay for cancer prevention clinical trials: serum retinol, retinyl palmitate, alpha-carotene and beta-carotene with the use of high-performance liquid chromatography. JNCI 79:975-982, 1987.

Roidt L, White EM, Goodman GE, Wahl PW, Omenn GS, Rollins B, Karkeck JM. Association of food frequency questionnaire estimates of vitamin A intake with serum vitamin A levels. Am J Epidemiol 128:645-654, 1988.

Goodman GE, Metch BJ, Omenn GS. The effect of long-term beta-carotene and vitamin A administration on serum concentrations of alpha-tocopherol. Cancer Epidemiol Biomarkers Prev 3:429-432, 1994.

Goodman GE, Thornquist M, Kestin M, Metch B, Anderson G, Omenn GS, and CARET Co-Investigators. The association between participant characteristics and serum concentrations of b-carotene, retinol, retinyl palmitate, and a-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer. Cancer Epidemiol Biomarkers Prev 5:815-821, 1996.

Redlich CA, Berglund L, Blaner WS, Chung JS, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology, Biomarkers & Prevention 7:211-214, March 1998.

Goodman GE, Schaffer S, Bankson DD, Hughes MP, Omenn GS and the CARET Co-Investigators. Predictors of serum selenium in cigarette smokers and lack of association with lung and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 10:1069-1076, 2001.

Spitz, MR, Barnett M, Goodman GE, Thornquist MD, Wu X, Pollak M. Serum IGF-1 and binding protein levels and risk of lung cancer: a case-control study nested in the CARET cohort. Cancer Epidemiology, Biomarkers & Prevention. 11:1413-1418, 2002.

Goodman GE, Schaffer MS, Omenn GS, Chen C, King I, CARET Co-Investigators. The association between lung or prostate cancer risk and serum micronutrients: Results and lessons learned from CARET. Cancer Epidemiology, Biomarkers & Prevention. 12:518-526, 2003.

Littman AJ, Jackson LA, White E, Thornquist MD, Gaydos C, Vaughan TL. Interlaboratory reliability of microimmunfluorescence test for measurement of Chlamydia pneumoniae - specific immunoglobulin A and G antibody titers. Clin Diag Lab Immunol. 11(3):615-617, 2004.

Littman AJ, Jackson LA, White E, Thornquist MD, Gaydos C, Goodman GE, Vaughan TL. Chlamydia pneumoniae infection and risk of lung cancer. Cancer Epidem, Biom & Prev. 13:1624-1630, Oct. 2004.

King IB, Kristal AR, Schaffer S, Thornquist M, Goodman GE. Serum Trans-Fatty Acids are associated with risk of prostate cancer in b-Carotene and Retinol Efficacy Trial. Cancer Epidem Biom Prev 14(4):988-992, April 2005.

Cartmel B, Dziura J, Cullen MR, Vegso, S, Omenn GS, Goodman GE, Redlich CA. Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET). Eur J Clin Nutr 59(10):1173-1180, Oct 2005.

Pereira-Faca SR, Kuick R, Puravs E, Zhang Q, Krasnoselsky AL, Phanstiel D, Qiu J, Misek DE, Hinderer R, Tammemagi M, Landi MT, Caporaso N, Pfeiffer R, Edelstein C, Goodman G, Barnett M, Thornquist M, Brenner D, Hanash SM. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. Cancer Res. 67(24):12000-6, Dec 2007.

Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med. 5(6):e123, Jun 10 2008.

Qiu J, Choi G, Li L, Wang H, Pitteri SJ, Pereira-Faca SR, Krasnoselsky AL, Randolph TW, Omenn GS, Edelstein C, Barnett MJ, Thornquist MD, Goodman GE, Brenner DE, Feng Z, Hanash SM. Occurrence of autoantibodies to annexin 1, 14-3-3 theta and LAMR1 in pre-diagnostic lung cancer sera. J Clin Oncol. 26(31):5060-6, Nov 1 2008. Epub Sep 15 2008.

Takata Y, King IB, Neuhouser ML, Schaffer S, Barnett M, Thornquist M, Peters U, Goodman GE. Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. Cancer Causes Control. 20(4):497-504, May 2009. Epub 3 Mar 2009.

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Dietary Studies
Key Paper
Neuhouser ML, Patterson RE, Thornquist MD, Omenn GS, King IB, Goodman GE. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidem, Biom & Prev. 12:350-358, 2003.
Other Papers
Omenn GS, Goodman GE, Kleinman GD, Rosenstock L, Barnhart S, Feigl P, Thomas DB, Kalman D, Lund B, Prentice RL, Henderson MM. The role of intervention studies in ascertaining the contribution of dietary factors in lung cancer: the Seattle chemoprevention trial of retinoids in asbestos-exposed workers. Ann NY Acad Sci 534:575-583, 1988.

Roidt L, White EM, Goodman GE, Wahl PW, Omenn GS, Rollins B, Karkeck JM. Association of food frequency questionnaire estimates of vitamin A intake with serum vitamin A levels. Am J Epidemiol 128:645-654, 1988.

Goodman GE, Schaffer S, Bankson DD, Hughes MP, Omenn GS and the CARET Co-Investigators. Predictors of serum selenium in cigarette smokers and lack of association with lung and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 10:1069-1076, 2001.

Goodman GE, Schaffer MS, Omenn GS, Chen C, King I, CARET Co-Investigators. The association between lung or prostate cancer risk and serum micronutrients: Results and lessons learned from CARET. Cancer Epidemiology, Biomarkers & Prevention. 12:518-526, 2003.

Neuhouser ML, Barnett MJ, Kristal AR, Ambrosone CB, King I, Thornquist MD, Goodman GE. (n-6) PUFA Increase and Dairy Foods Decrease Prostate Cancer Risk in Heavy Smokers. J Nutr. 137(7):1821-7, Jul 2007.

Choi JY, Neuhouser ML, Barnett M, Hong CC, Kristal AR, Thornquist M, King IB, Goodman G, Ambrosone CB. Iron intake, oxidative stress-related genes (MnSOD and MPO), and prostate cancer risk in CARET cohort. Carcinogenesis. 29(5): 964-70, May 2008. Epub Feb 22 2008.

Takata Y, King IB, Neuhouser ML, Schaffer S, Barnett M, Thornquist M, Peters U, Goodman GE. Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. Cancer Causes Control. 20(4):497-504, May 2009. Epub 3 Mar 2009.

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Genetic Analysis
Chen C, Lamharzi N, Weiss NS, Etzioni R, Dightman DA, Barnett M, DiTommaso D, Goodman G. Androgen receptor polymorphisms and the incidence of prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 11:1033-1040, 2002.

Lamharzi N, Johnson, M, Goodman GE, Etzioni R, Weiss NS, Dightman DA, Barnett M, DiTommaso D, Chen C. Polymorphic markers in the 5a-reductase type II gene and the incidence of prostate cancer. International Journal of Cancer. 105:480-483, 2003.

Chen C, Weiss NS, Stanczyk S, Lewis K, Dante D, Etzioni R, Barnett M, Goodman, GE. Endogenous sex hormones and prostate cancer risk: A case-control study nested within the Carotene and Retinol Efficacy Trial. Cancer Epidem, Biom & Prev 12:1410-1416, Dec 2003.

Choi JY, Neuhouser ML, Barnett M, Hudson M, Kristal AR, Thornquist M, King IB, Goodman GE, Ambrosone CB. Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. Cancer Epidemiol Biomarkers Prev. 16(6):1115-20, Jun 2007.

Boger-Megiddo I, Weiss NS, Barnett MJ, Goodman GE, Chen C. V89L Polymorphism of the 5a-Reductase Type II Gene (SRD5A2), Endogenous Sex Hormones, and Prostate Cancer Risk. Cancer Epidemiol Biomarkers Prev. 17(2):286-91, Feb 2008.

Choi JY, Neuhouser ML, Barnett M, Hong CC, Kristal AR, Thornquist M, King IB, Goodman G, Ambrosone CB. Iron intake, oxidative stress-related genes (MnSOD and MPO), and prostate cancer risk in CARET cohort. Carcinogenesis. 29(5): 964-70, May 2008. Epub Feb 22 2008.

Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field J, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcatova I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway DI, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 452:633-7, Apr 2008.

McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A; EPIC Study, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 40(12):1404-6, Dec 2008. Epub 2 Nov 2008.

Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, Lemarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P. International lung cancer consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Cancer Epidemiol Biomarkers Prev. 17(11):3081-9, Nov 2008.

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Intervention Effect
Key Papers
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. NEJM 334:1150-1155, 1996.

Omenn G, Goodman G, Thornquist M, Balmes J, Cullen M, Glass A, Keogh J, Meyskens F, Valanis B, Williams J, Barnhart S, Cherniack M, Brodkin C, Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the beta-Carotene and Retinol Efficacy Trial. JNCI 88:1550-9, 1996.

Goodman, GE, Thornquist MD, Balmes J, Cullen MR, Meyskens F, Omenn GS, Valanis B, Williams J. The Beta-Carotene and Retinol Efficacy Trial: Incidence of Lung Cancer and Cardiovascular Disease Mortality During 6-Year Follow-up After Stopping ?-Carotene and Retinol Supplements. Journal of the National Cancer Institute. 96(23):1743-1750, Dec 2004.

Other Papers
Goodman GE, Metch BJ, Omenn GS. The effect of long-term beta-carotene and vitamin A administration on serum concentrations of alpha-tocopherol. Cancer Epidemiol Biomarkers Prev 3:429-432, 1994.

Omenn GS, Goodman GE, Thornquist M, Brunzell JD. Long term vitamin A does not produce clinically significant hypertriglyceridemia: results from CARET, the b-Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev 3:711-713, 1994.

Redlich CA, Blaner WS, Carter D, Wirth JA, Tanoue LT, Van Bennekum AM,Holm CT, Cullen MR. Vitamin A chemoprevention of lung cancer: a short-term biomarker study. Adv Exp Med Biol 375:17-29, 1995.

Chuwers P, Barnhart S, Blanc P, Brodkin CA, Cullen M, Kelly T, Keogh J, Omenn G, Williams J, Balmes J. The protective effect of beta-carotene and retinol on ventilatory function in an asbestos-exposed cohort. Am J Respir & Critical Care Med 155:1066-1071, 1997.

Redlich CA, Berglund L, Blaner WS, Chung JS, Cullen MR. Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels. Cancer Epidemiology, Biomarkers & Prevention 7:211-214, March 1998.

Redlich C, Chung JS, Berglund L, Blaner WS, VanBennekum AM, Ramakrishnan R, Cullen MR. Effect of long term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 143(2):427-434, 1999.

Neuhouser ML, Patterson RE, Thornquist MD, Omenn GS, King IB, Goodman GE. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidem, Biom & Prev. 12:350-358, 2003.

Cartmel B, Dziura J, Cullen MR, Vegso, S, Omenn GS, Goodman GE, Redlich CA. Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET). Eur J Clin Nutr 59(10):1173-1180, Oct 2005.

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Prevention Trial Studies
Key Papers
Goodman GE. The clinical evaluation of cancer chemoprevention agents: defining and contrasting phase I, II, and III objectives. Cancer Res 52:2752S-2757S, 1992.

Goodman G, Valanis B, Meyskens F, Williams J, Metch B, Thornquist M, Omenn G. Strategies for recruitment to a population-based lung cancer prevention trial: the CARET experience with heavy smokers. Cancer Epidemiology, Biomarkers & Prevention 7:405-412, 1998

Bowen D, Cartmel B, Barnett M, Goodman G, Omenn G. Predictors of retention in two chemoprevention trials. Annals of Behav Med 21(3):210-215, 1999.

Bowen DJ, Thornquist M, Anderson K, Barnett M, Powell C, Goodman G, Omenn G Stopping the active intervention: CARET. Controlled Clinical Trials. 24:39-50, 2003.

Other Papers
Thornquist MD, Patrick DL, and Omenn GS. Participation and adherence among older men and women recruited to the beta-Carotene and Retinol Efficacy Trial (CARET) to prevent lung cancer in heavy smokers and in asbestos-exposed workers. Gerontologist 31:593-597, 1991.

Omenn GS, Goodman G, Grizzle J, Thornquist M, Rosenstock L, Barnhart J, Anderson G, Balmes J, Cone J, Cherniack M, Cullen M, Glass A, Valanis B, Keogh J, Meyskens FL Jr, Williams J Jr. Recruitment for CARET, the beta-Carotene and Retinol Efficacy Trial to prevent lung cancer in smokers and asbestos-exposed workers. West J Med 156:540-544, 1992.

Thornquist M, Urban N, Tseng A, Edelstein C, Lund B, Omenn GS. Research cost analyses to aid in decision making in the conduct of a large prevention trial, CARET. Controlled Clin Trials 14:325-339, 1993.

Goodman GE. Chemoprophylaxis strategies in high-risk groups with an emphasis on lung cancer. Chest 103:60S-62S, 1993.

Goodman GE. Cancer prevention: chemoprevention vs dietary modifications. Prev Med 22:689-692, 1993.

Goodman GE. Cancer prevention: contrasting dietary modification with intervention agents. In: Bertino JR, ed. Encyclopedia of Cancer. San Diego, CA: Academic Press Vol 1:199-206, 1997.

Omenn GS. Interpretations of the Linxian vitamin supplement chemoprevention trials. Epidemiology 9(1):1-4, January 1998.

Valanis B, Glass A, Blank J. Mailing strategies and costs of recruiting heavy smokers in CARET, a large chemoprevention trial. Controlled Clin Trials 19:25-38, February 1998.

Bowen D, Thornquist M, Anderson K, Barnett M, Goodman G, Valanis B, Omenn G. Effects of incentive items on participation in a randomized chemoprevention trial. Jnl of Health Psych 5(1) 109-115; 2000.

Goodman GE. Prevention of lung cancer. Critical Reviews in Oncology/Hematology. 33:187-197, 2000.

Thornquist MD, Edelstein C, Goodman GE, Omenn GS. Streamlining IRB review in multisite trials through single-study IRB Cooperative Agreements: experience of the B-Carotene and Retinol Efficacy Trial (CARET). Controlled Clinical Trials 23:80-86, 2002.

Goodman GE, Alberts DS, Meyskens FL. Retinol, Vitamins, and Cancer Prevention: 25 Years of Learning and Relearning. J Clin Oncol. Epub 3 Nov 2008.

Goodman GE. Assessing Toxicity in Cancer Chemoprevention Trials: The Other Side of the Coin. Cancer Prev Res. 1(7):499-502, 1 Dec 2008.

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Biorepositories
Goodman GE, Thornquist MD, Edelstein C, Omenn GS. Biorepositories: Let’s Not Lose What We Have So Carefully Gathered! Cancer Epidemiol Biomarkers Prev 15(4):599-601, Apr 2006.

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Lung Cancer
Key Papers
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. NEJM 334:1150-1155, 1996.

Omenn G, Goodman G, Thornquist M, Balmes J, Cullen M, Glass A, Keogh J, Meyskens F, Valanis B, Williams J, Barnhart S, Cherniack M, Brodkin C, Hammar S. Risk factors for lung cancer and for intervention effects in CARET, the beta-Carotene and Retinol Efficacy Trial. JNCI 88:1550-9, 1996.

Goodman, GE, Thornquist MD, Balmes J, Cullen MR, Meyskens F, Omenn GS, Valanis B, Williams J. The Beta-Carotene and Retinol Efficacy Trial: Incidence of Lung Cancer and Cardiovascular Disease Mortality During 6-Year Follow-up After Stopping ?-Carotene and Retinol Supplements. Journal of the National Cancer Institute. 96(23):1743-1750, Dec 2004.

Other Papers
Brodkin C, McCullough J, Stover B, Balmes J, Hammar S, Omenn G, Checkoway H, Barnhart S. Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial. Am J Ind Med 32:582-591, December 1997.

Goodman GE, Schaffer S, Bankson DD, Hughes MP, Omenn GS and the CARET Co-Investigators. Predictors of serum selenium in cigarette smokers and lack of association with lung and prostate cancer risk. Cancer Epidemiol Biomarkers Prev 10:1069-1076, 2001.

Spitz, MR, Barnett M, Goodman GE, Thornquist MD, Wu X, Pollak M. Serum IGF-1 and binding protein levels and risk of lung cancer: a case-control study nested in the CARET cohort. Cancer Epidemiology, Biomarkers & Prevention. 11:1413-1418, 2002.

Bach PB, Kattan MW, Thornquist MD, Kris MG, Tate RC, Barnett MJ, Hsieh LJ, Begg CB. Variations in Lung cancer risk among smokers. Jnl Nat Cancer Inst. 95(6):470-478, 2003.

Neuhouser ML, Patterson RE, Thornquist MD, Omenn GS, King IB, Goodman GE. Fruits and vegetables are associated with lower lung cancer risk only in the placebo arm of the beta-carotene and retinol efficacy trial (CARET). Cancer Epidemiol Biomarkers Prev. 12:350-358, 2003.

Littman AJ, Jackson LA, White E, Thornquist MD, Gaydos C, Goodman GE, Vaughan TL. Chlamydia pneumoniae infection and risk of lung cancer. Cancer Epidemiol Biomarkers Prev. 13:1624-1630, Oct. 2004.

Littman AJ, Jackson LA, White E, Thornquist MD, Goodman GE, Vaughan TL. Prior lung diseases and risk of lung cancer in a large prospective cohort study. Cancer Causes and Control 15(8):819-827, Oct. 2004.

Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich C, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS. Predictors of lung cancer among asbestos-exposed men in the b-carotene and retinol efficacy trial. Am J Epidemiol 161: 260-270, Feb 2005.

Goodman GE, Omenn GS, Feigl P, Kleinman GD, Lund B, Thomas DB, Henderson MM, Prentice R. Chemoprevention of lung cancer with retinol/beta-carotene. In: Meyskens FL and Prasad KN, eds. Vitamins and Cancer: Human Cancer Prevention by Vitamins and Micronutrients. Clifton, New Jersey: Humana Press. p. 341-350, 1985.

Omenn GS, Goodman GE, Rosenstock L, Barnhart S, Lund B, Thornquist M, Feigl P. Cancer chemoprevention with vitamin A and beta-carotene in populations at high risk for lung cancer. In: Cerutti PA, Nygaard OF, Simic MG, eds. Anticarcinogenesis and Radiation Protection. New York: Plenum Press 279-283, 1988.

Omenn GS. A double-blind randomized trial with beta-carotene and retinol in persons at high risk of lung cancer due to occupational asbestos exposures and/or cigarette smoking. Public Health Rev 16:99-125, 1988.

Omenn GS, Goodman GE, Thornquist M, Rosenstock L, Barnhart S, Feigl P. Chemoprevention of lung cancer with beta-carotene and retinol in persons at high risk due to asbestos occupational exposures and/or cigarette smoking: a double-blind randomized trial. In: Wehner AP, ed. Biological Interaction of Inhaled Mineral Fibers and Cigarette Smoke. Columbus (OH): Batelle Press 121-143, 1989.

Omenn GS. Chemoprevention of occupationally related lung cancer. Washington Public Health 7:35-36, 1989.

Goodman GE. Chemoprophylaxis strategies in high-risk groups with an emphasis on lung cancer. Chest 103:60S-62S, 1993.

Redlich CA, Blaner WS, Carter D, Wirth JA, Tanoue LT, Van Bennekum AM, Holm CT, Cullen MR. Vitamin A chemoprevention of lung cancer: a short-term biomarker study. Adv Exp Med Biol 375:17-29, 1995.

Goodman GE. Prevention of lung cancer. Thorax 57:994-999, 2002.

Goodman GE, Schaffer MS, Omenn GS, Chen C, King I, CARET Co-Investigators. The association between lung or prostate cancer risk and serum micronutrients: Results and lessons learned from CARET. Cancer Epidemiol Biomarkers Prev. 12:518-526, 2003.

Alfano CM, Klesges RC, Murray DM, Bowen DJ, McTiernan A, Vander Weg MW, Robinson LA, Cartmel B, Thornquist MD, Barnett M, Goodman GE, Omenn GS. Physical activity in relation to all-site and lung cancer incidence and mortality in current and former smokers. Cancer Epidemiol Biomarkers Prev. 13:2233-2241, Dec 2004.

Chien JW, Au DH, Barnett MJ, Goodman GE. Spirometry, Rapid FEV1 Decline, and Lung Cancer Among Asbestos Exposed Heavy Smokers. Journal of Chronic Obstructive Pulmonary Disease. 4:339-346, Dec 2007.

Pereira-Faca SR, Kuick R, Puravs E, Zhang Q, Krasnoselsky AL, Phanstiel D, Qiu J, Misek DE, Hinderer R, Tammemagi M, Landi MT, Caporaso N, Pfeiffer R, Edelstein C, Goodman G, Barnett M, Thornquist M, Brenner D, Hanash SM. Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer. Cancer Res. 67(24):12000-6, Dec 2007.

Hung RJ, McKay JD, Gaborieau V, Boffetta P, Hashibe M, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Chen C, Goodman G, Field J, Liloglou T, Xinarianos G, Cassidy A, McLaughlin J, Liu G, Narod S, Krokan HE, Skorpen F, Elvestad MB, Hveem K, Vatten L, Linseisen J, Clavel-Chapelon F, Vineis P, Bueno-de-Mesquita HB, Lund E, Martinez C, Bingham S, Rasmuson T, Hainaut P, Riboli E, Ahrens W, Benhamou S, Lagiou P, Trichopoulos D, Holcatova I, Merletti F, Kjaerheim K, Agudo A, Macfarlane G, Talamini R, Simonato L, Lowry R, Conway DI, Znaor A, Healy C, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 452:633-7, Apr 2008.

Qiu J, Choi G, Li L, Wang H, Pitteri SJ, Pereira-Faca SR, Krasnoselsky AL, Randolph TW, Omenn GS, Edelstein C, Barnett MJ, Thornquist MD, Goodman GE, Brenner DE, Feng Z, Hanash SM. Occurrence of autoantibodies to annexin 1, 14-3-3 theta and LAMR1 in pre-diagnostic lung cancer sera. J Clin Oncol. 26(31):5060-6, Nov 1 2008. Epub Sep 15 2008.

McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A; EPIC Study, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P. Lung cancer susceptibility locus at 5p15.33. Nat Genet. 40(12):1404-6, Dec 2008. Epub 2 Nov 2008.

Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, Lemarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P. International lung cancer consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Cancer Epidemiol Biomarkers Prev. 17(11):3081-9, Nov 2008.

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Breast Cancer
Takata Y, King IB, Neuhouser ML, Schaffer S, Barnett M, Thornquist M, Peters U, Goodman GE. Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. Cancer Causes Control. 20(4):497-504, May 2009. Epub 3 Mar 2009.

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Colon Cancer
Aliyu OA, Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Israel L, Goodman GE, Thornquist MD, Omenn GS. Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial. Am J Epidemiol 162(9):868-78, Nov 2005.

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Pancreatic Cancer
Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med. 5(6):e123, Jun 10 2008.

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Prostate Cancer
Key Paper
Chen C, Weiss NS, Stanczyk S, Lewis K, Dante D, Etzioni R, Barnett M, Goodman, GE. Endogenous sex hormones and prostate cancer risk: A case-control study nested within the Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev 12:1410-1416, Dec 2003.
Other Papers
Etzioni R, Pepe M, Longton G, Hu C, Goodman G. Incorporating the time dimension in receiver operating characteristic curves: a case study of prostate cancer. Medical Decision Making 19: 242-251, 1999.

Ellis WJ, Etzioni R, Vessella RL, Goodman GE. Serial prostate specific antigen, free/total PSA ration, and complexed PSA in the diagnosis of prostate cancer. Jnl of Urology 166:93-98, 2001.

Chen C, Lamharzi N, Weiss NS, Etzioni R, Dightman DA, Barnett M, DiTommaso D, Goodman G. Androgen receptor polymorphisms and the incidence of prostate cancer. Cancer Epidemiology, Biomarkers & Prevention 11:1033-1040, 2002.

Goodman GE, Schaffer MS, Omenn GS, Chen C, King I, CARET Co-Investigators. The association between lung or prostate cancer risk and serum micronutrients: Results and lessons learned from CARET. Cancer Epidemiol Biomarkers Prev. 12:518-526, 2003.

Lamharzi N, Johnson, M, Goodman GE, Etzioni R, Weiss NS, Dightman DA, Barnett M, DiTommaso D, Chen C. Polymorphic markers in the 5a-reductase type II gene and the incidence of prostate cancer. International Journal of Cancer. 105:480-483, 2003.

King IB, Kristal AR, Schaffer S, Thornquist M, Goodman GE. Serum Trans-Fatty Acids are associated with risk of prostate cancer in b-Carotene and Retinol Efficacy Trial. Cancer Epidem Biom Prev 14(4):988-992, April 2005.

Choi JY, Neuhouser ML, Barnett M, Hudson M, Kristal AR, Thornquist M, King IB, Goodman GE, Ambrosone CB. Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. Cancer Epidemiol Biomarkers Prev. 16(6):1115-20, Jun 2007.

Neuhouser ML, Barnett MJ, Kristal AR, Ambrosone CB, King I, Thornquist MD, Goodman GE. (n-6) PUFA Increase and Dairy Foods Decrease Prostate Cancer Risk in Heavy Smokers. J Nutr. 137(7):1821-7, Jul 2007.

Boger-Megiddo I, Weiss NS, Barnett MJ, Goodman GE, Chen C. V89L Polymorphism of the 5a-Reductase Type II Gene (SRD5A2), Endogenous Sex Hormones, and Prostate Cancer Risk. Cancer Epidemiol Biomarkers Prev. 17(2):286-91, Feb 2008.

Choi JY, Neuhouser ML, Barnett M, Hong CC, Kristal AR, Thornquist M, King IB, Goodman G, Ambrosone CB. Iron intake, oxidative stress-related genes (MnSOD and MPO), and prostate cancer risk in CARET cohort. Carcinogenesis. 29(5): 964-70, May 2008. Epub Feb 22 2008.

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Cardiovascular Disease
Key Papers
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL, Valanis B, Williams JH, Barnhart S, Hammar S. Effects of a combination of beta-carotene and vitamin A on lung cancer and cardiovascular disease. NEJM 334:1150-1155, 1996.

Goodman, GE, Thornquist MD, Balmes J, Cullen MR, Meyskens F, Omenn GS, Valanis B, Williams J. The Beta-Carotene and Retinol Efficacy Trial: Incidence of Lung Cancer and Cardiovascular Disease Mortality During 6-Year Follow-up After Stopping ?-Carotene and Retinol Supplements. Journal of the National Cancer Institute. 96(23):1743-1750, Dec 2004.

Other Papers
Omenn GS, Beresford SAA, Motulsky AG. Preventing coronary heart disease: B vitamins and homocysteine. Circulation 97:421-424, February 1998

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Asbestosis
Key Papers
Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich C, Brodkin CA, Barnhart S, Rosenstock L, Goodman GE, Hammar SP, Thornquist MD, Omenn GS. Predictors of lung cancer among asbestos-exposed men in the b-carotene and retinol efficacy trial. Am J Epidemiol 161: 260-270, Feb 2005.

Barnhart S, Keogh J, Cullen M, Brodkin C, Liu D, Goodman G, Valanis B, Glass A, Thornquist M, Rosenstock L, Omenn G, Balmes J. The CARET asbestos-exposed cohort: baseline characteristics and comparison to other asbestos-exposed cohorts. Am J Ind Med 32:573-581, December 1997.

Barnhart S, Thornquist M, Omenn G, Goodman G, Feigl P, Rosenstock L. The degree of roentgenographic parenchymal opacities attributable to smoking among asbestos-exposed subjects. Am Rev Respir Dis 141:1102-1106, 1990.

Other Papers
Brodkin CA, Barnhart S, Anderson G, Checkoway H, Omenn GS, Rosenstock L. Correlation between respiratory symptoms and pulmonary function in asbestos-exposed workers. Am Rev Respir Dis 148:32-37, 1993.

Brodkin CA, Barnhart S, Checkoway H, Balmes J, Omenn GS, Rosenstock L. Longitudinal pattern of reported respiratory symptoms and accelerated ventilatory loss in asbestos-exposed workers. Chest 109:120-126, 1996.

Chuwers P, Barnhart S, Blanc P, Brodkin CA, Cullen M, Kelly T, Keogh J, Omenn G, Williams J, Balmes J. The protective effect of beta-carotene and retinol on ventilatory function in an asbestos-exposed cohort. Am J Respir & Critical Care Med 155:1066-1071, 1997.

Brodkin C, McCullough J, Stover B, Balmes J, Hammar S, Omenn G, Checkoway H, Barnhart S. Lobe of origin and histologic type of lung cancer associated with asbestos exposure in the Carotene and Retinol Efficacy Trial. Am J Ind Med 32:582-591, December 1997.

Aliyu OA, Cullen MR, Barnett MJ, Balmes JR, Cartmel B, Redlich CA, Brodkin CA, Barnhart S, Rosenstock L, Israel L, Goodman GE, Thornquist MD, Omenn GS. Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial. Am J Epidemiol 162(9):868-78, Nov 2005.

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Chronic Obstructive Pulmonary Disease
Key Paper
Chuwers P, Barnhart S, Blanc P, Brodkin CA, Cullen M, Kelly T, Keogh J, Omenn G, Williams J, Balmes J. The protective effect of beta-carotene and retinol on ventilatory function in an asbestos-exposed cohort. Am J Respir & Critical Care Med 155:1066-1071, 1997.
Other Papers
Brodkin CA, Barnhart S, Anderson G, Checkoway H, Omenn GS, Rosenstock L. Correlation between respiratory symptoms and pulmonary function in asbestos-exposed workers. Am Rev Respir Dis 148:32-37, 1993.

Brodkin CA, Barnhart S, Checkoway H, Balmes J, Omenn GS, Rosenstock L. Longitudinal pattern of reported respiratory symptoms and accelerated ventilatory loss in asbestos-exposed workers. Chest 109:120-126, 1996.

Littman AJ, Jackson LA, White E, Thornquist MD, Goodman GE, Vaughan TL. Prior lung diseases and risk of lung cancer in a large prospective cohort study. Cancer Causes and Control 15(8):819-827, Oct. 2004.

Chien JW, Au DH, Barnett MJ, Goodman GE. Spirometry, Rapid FEV1 Decline, and Lung Cancer Among Asbestos Exposed Heavy Smokers. Journal of Chronic Obstructive Pulmonary Disease. 4:339-346, Dec 2007.

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