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Disease

 • Lung Cancer

 • Breast Cancer

 • Colon Cancer

 • Liver Cancer

 • Ovarian Cancer

 • Pancreatic Cancer

 • Multiple Cancers

Types of Study

 • Dietary/ Micronutrient Studies

Pilot & Other Unpublished Studies

Active Studies


Lung Cancer
Title: Investigating regions of identity-by-descent associated with lung cancer risk and smoking behaviors
Investigator: Aldrich, Melinda
Institution: Vanderbilt-Ingram Cancer Center
Objective: To identify regions of identity-by-descent associated with lung cancer risk; to identify regions associated with smoking behavior through identity-by descent mapping.
   
Title: Analyzing SNP data on lung/melanoma to investigate whether HLA class I and II associations with cancer are enhanced by the presence of genes encoding iKIRs
Investigator: Asquith, Becca
Institution: Imperial College of London
Objective:  
   
Title: Evaluating associations between lung cancer risk variants and second primary lung cancer (SPLC)
Investigator: Han, Summer
Institution: Stanford University
Objective: To evaluate the genetic, environmental, and clinical determinants of developing second-primary lung cancer (SPLC) among survivors of initial lung cancers using population-based data methods; cohort data from ILCCO and TRICL will be used to identify genetic, clinical, and environmental risk factors for SPLC, which include SNPs, smoking, radiation therapy, COPD, gender, education, race, BMI, and initial primary lung cancer characteristics.
   
Title: Associations between comorbidity and lung cancer survival: Effect of ethnicity, and modifying effect of smoking and other environmental exposures
Investigator: Liu, Geoffrey
Institution: Princess Margaret Cancer Center (Toronto)
Objective: To assess the effect of comorbidity on lung cancer survival across different ethnic backgrounds (specifically, Caucasian and Asian; exploratory African-American due to limited sample size); To evaluate whether cigarette smoking modifies the relationship between comorbidity and prognosis in lung cancer patients; To explore the role of other lifestyles and environmental exposures (such as asbestos exposure, alcohol exposure, and marijuana use) as modifiers of the relationship between comorbidity and prognosis in lung cancer patients; To assess the effect of comorbidity on likelihood of receiving lung cancer treatment including surgery, radiation, systemic therapy.
   
Title: Development and validation of lung cancer risk prediction models
Investigator: Tammemagi, Martin
Institution: Brock University Applied Health Sciences
Objective: 1. In CARET data, to externally validate existing lung cancer risk prediction models in their ability to predict incident lung cancers2-10, and lung cancer mortality. Almost all of the currently published models have been designed to identify becoming a lung cancer case. But some recent discussion regarding selection criteria for screening has suggested identification of those who will die from lung cancer may also be relevant. 2. To validate the Tammemagi 2012 Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) model9 into which asbestos has been synthetically added as predictors. And if found to be deficient use CARET data to improve the parameter estimates for asbestos in the Tammemagi 2012 model. 3. To develop and validate lung cancer risk prediction models for never-smokers (if data permits).
   
Title: Validation and updating lung cancer risk models
Investigator: Teare, M. Dawn
Institution: University of Sheffield School of Health and Related Research
Objective: 1) To identify and review all existing lung cancer risk models (LCRMS). Pay attention to the features of the target population the model was developed for; 2) To evaluate the performance of LCRMs when applied to populations similar and distinct to those developed for. This will produce aggregate data to take to the next stage.(Using ILCCO participating studies); 3) To systematically review and apply the multivariate analyses to combine the evidence for each component predictor and evaluate the performance. Following a framework such as outlined by Gasparini which can handle non linear associations; 4) To formulate a robust and flexible means to assess lung cancer risk.
   

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Breast Cancer
Title: Family history and cancer risk and mortality
Investigator: Genkinger, Jeanine
Institution: Columbia University
Objective: To improve risk assessment and ID factors that could lead to reduced risk and increased screening efficacy of site-specific cancers across the spectrum of familial risk and for people with strong family histories of cancer diseases.
   
Title: Overall and subtype-specific breast cancer risk prediction for stratified prevention
Investigator: Kraft, Peter
Institution: Harvard University
Objective: To assimilate and analyze data on >1.5 million US women from the NCI Cohort Consortium Study to develop a comprehensive tool that will predict breast cancer risk, overall and by sub-types, across major ethnic groups in the US.
   
Title: Prediagnostic Vit D & mortality in breast cancer: a pooled analysis
Investigator: Visvanathan, Kala
Institution: Johns Hopkins
Objective: To determine whether pre-diagnostic circulating vitamin D levels are associated with improved survival in patients with breast cancer in the context of the Vitamin D Pooling Project of Breast and Colorectal Cancer, a large consortium of 20 prospective cohort studies from the United States, Europe, and Japan.
   

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Colon Cancer
Title: Pooled Analysis of 25-hydroxy Vitamin D and Colorectal Cancer Survival (Harvard Pooling project)
Investigator: Fedirko, Veronica
Institution: Emory University School of Public Health
Objective: To investigate association between pre-diagnostic 25(OH)D levels and CRC-specific and overall mortality among CRC cases in the VDPP project.
   
Title: Diabetes and Cancer Initiative in the Cohort Consortium
Investigator: Gunter, Marc
Institution: Imperial College of London
Objective: To further understand the relation of diabetes with cancer both in terms of epidemiology and underlying molecular mechanisms.
   

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Liver Cancer
Title: Metabolomics, bacterial translocation, and risk of liver cancer: a proposed study within the LCPP and other US based cohorts
Investigator: McGlynn, Katherine
Institution: National Institutes of Health/National Cancer Institute
Objective: To determine the association between metabolites and liver cancer incidence.
   

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Ovarian Cancer
Title: Antibodies to HE4 and mesothelin predictive for future ovarian cancer
Investigator: Hellstrom, Ingegerd
Institution: University of Washington
Objective: To investigate whether antibodies to two biomarkers, mesothelin and HE4, are related to the development of ovarian carcinoma (OvC) by being more frequently detected in sera from symptom-free women who later developed OvC cancer than in sera from women who did not.
   
Title: Detection of Epithelial Ovarian Cancer in CARET study using H-NMR metabonomics
Investigator: Odunsi, Kunle
Institution: Roswell Park Cancer Institute Gynecologic Oncology
Objective: To validate 1H-NMR based on metabonomics for early detection utilizing samples from the Carotene and Retinol Efficacy Trial (CARET) study. The primary goal is to evaluate, as a function of time before clinical diagnosis, the capacity of metabonomics to detect preclinical disease. Specimens obtained within 3 years of the closet time point to diagnosis from ovarian cancer cases will be tested utilizing NMR metabonomics.
   
Title: miRNA Biomarkers for Early Ovarian Cancer Detection
Investigator: Tewari, Maneesh
Institution: Fred Hutchinson Cancer Research Center Human Biology
Objective: To assess performance of miR-135b as a single biomarker in pre-clinical samples from the Carotene and Retinol Efficacy Trial (CARET) repository. Secondary analyses will include sensitivity using the PEB longitudinal algorithm, sensitivity at other levels of specificity, contribution to a decision rule including CA125, HE4, and Mesothelin and evaluation of miR-135b in a risk algorithm.
   

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Pancreatic Cancer
Title: Biomarker for early detection of pancreatic cancer
Investigator: Chen, Ru
Institution: University of Washington
Objective: To evaluate proteomics biomarkers in detecting pancreatic cancer at asymptomatic or pre-cancer stages.
   

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Multiple Cancers
Title: A Pooling Project on Alcohol Use and Risk of Cancers with Inconsistent Prior Evidence, with an Emphasis in Non-Smokers
Investigator: Ferrari, Pietro
Institution: IARC and Harvard University
Objective: To estimate the burden of alcohol consumption on site-specific cancer incidence and total and cause-specific mortality using data from the NCI Cohort consortium; dose-response relationships will be investigated using baseline and lifetime alcohol uses.
   

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Dietary/Micronutrient Studies
Title: Pooled Analysis of 25-hydroxy Vitamin D and Colorectal Cancer Survival (Harvard Pooling project)
Investigator: Fedirko, Veronica
Institution: Emory University School of Public Health
Objective: To investigate association between pre-diagnostic 25(OH)D levels and CRC-specific and overall mortality among CRC cases in the VDPP project.
   
Title: A Pooling Project on Alcohol Use and Risk of Cancers with Inconsistent Prior Evidence, with an Emphasis in Non-Smokers
Investigator: Ferrari, Pietro
Institution: IARC and Harvard University
Objective: To estimate the burden of alcohol consumption on site-specific cancer incidence and total and cause-specific mortality using data from the NCI Cohort consortium; dose-response relationships will be investigated using baseline and lifetime alcohol uses.
   
Title: Prediagnostic Vit D & mortality in breast cancer: a pooled analysis
Investigator: Visvanathan, Kala
Institution: Johns Hopkins
Objective: To determine whether pre-diagnostic circulating vitamin D levels are associated with improved survival in patients with breast cancer in the context of the Vitamin D Pooling Project of Breast and Colorectal Cancer, a large consortium of 20 prospective cohort studies from the United States, Europe, and Japan.
   

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