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Scientific Board of Directors

Mark Thornquist, Ph.D., is a Full Member in the Division of Public Health Sciences at the Fred Hutchinson Cancer Research Center (FHCRC) and was the Director of COMPASS. Dr. Thornquist served as the director of the coordinating center for six projects, of which four were funded by NIH and two by industry:

  • Co-Investigator and lead statistician on the Carotene and Retinol Efficacy Trial (CARET) since 1985 and director of the CARET Coordinating Center since 1995. He is responsible for the analytic methods used to design, monitor, and analyze CARET data. In addition, he directs all activities associated with the extensive CARET specimen bank and data, provides scientific expertise for all CARET ancillary studies, and acts as chair of the CARET Publication Committee.
  • Principal Investigator, lead statistician, and director of the Coordinating Center for the Olestra Post-Marketing Surveillance Study (OPMSS) from 1996 to 2000, with responsibility for all aspects of the study’s design and execution. He continues to direct the use of the OPMSS specimen bank in support of the OPMSS investigators.
  • Co-Principal Investigator since 2000 and Multi-PI since 2016 for the Early Detection Research Network (EDRN): Data Management and Coordinating Center (DMCC) and director for the operational aspects of the DMCC through the fall of 2018. He is the chair of EDRN’s Data Sharing and Informatics Subcommittee and directs the informatics infrastructure development in EDRN in collaboration with the Jet Propulsion Laboratories. He is the lead statistician for the Breast Collaborative Group in EDRN.
  • Principal Investigator for the Transdisciplinary Research on Energetics and Cancer (TREC) Coordination Center through 2016; he was responsible for all scientific and operational activities of the Coordination Center, has chaired the TREC Steering Committee, chaired the Evaluation Subcommittee, and chaired the Data Sharing and Management Working Group.
  • Principal Investigator and lead statistician for the Coordinating Center for Clinical Correlative Studies (CCS) for the Tyrosine Kinase Optimization Study (TOPS) from 2007 to 2012; he directed the development of data systems to exchange specimens and data, and designed and analyzed correlative studies using the TOPS specimens and data.
  • Co-Principal Investigator through 2017 for the Statistical Coordinating Center (SCC) for the Population-based Research Optimizing Screening through Personalized Regimens (PROSPR I) initiative. He directed data operations for the central data repository and was the SCC statistician for the Cervical Working Group.
  • Co-investigator and statistician for the Coordinating Center for the Asian Cohort Consortium (ACC), with responsibility for assembling and analyzing data from over 20 cohorts with over a million participants.
Gary Goodman, M.D., M.S., served as the Principal Investigator (PI) of the Carotene and Retinol Efficacy Trial (CARET) and chair of the CARET Steering Committee until April of 2018. Dr. Goodman has been primarily responsible for the overall design of the CARET trial with his experience as a clinical investigator in lung cancer clinical trials. He was responsible for the development of methodology to assess participants for side effects and the laboratory serum vitamin assay. As the Principal Investigator of CARET, Dr. Goodman was responsible for the overall direction of the trial and maintenance of the specimen repository. Dr. Goodman holds a joint membership with the Fred Hutchinson Cancer Research Center and the Swedish Cancer Institute. Dr. Goodman received his M.D. and M.S. in Pharmacology from the University of Illinois in 1974.

Marian Neuhouser, Ph.D., is a nutritional epidemiologist and head of the Cancer Prevention Program, with considerable experience in dietary assessment and biomarkers of diet. Dr. Neuhouser co-leads the Fred Hutchinson Cancer Research Center’s Nutrition Assessment Shared Resource. In this capacity, she has helped to develop food frequency questionnaires used in large studies such as the Selenium and Vitamin E Cancer Prevention Trial and A Cohort Study of Dietary Supplements and Cancer Risk. Dr. Neuhouser also oversees the updates and maintenance of the dietary databases used to support the Food Frequency Questionnaires (FFQs) and is well-acquainted with the challenges of blending data collected with multiple instruments across various dietary database versions. In addition, Dr. Neuhouser serves as the scientific contact point for NIH-funded studies that use the FHCRC FFQs; she consults with investigators about study design and analysis of dietary data collected with these FFQs. Dr. Neuhouser has worked with Dr. Thornquist in large multi-center clinical trials and observational studies involving diet including the Olestra Post-Marketing Surveillance Study (OPMSS) and Carotene and Retinol Efficacy Trial (CARET). She is currently very active in the Women’s Health Initiative Clinical Coordinating Center. Dr. Neuhouser also brings experience in developing dietary assessment instruments for children, non-English speakers, and persons with low literacy skills. For example, as a part of A Community Randomized Trial for Cancer Prevention, she developed a dietary assessment tool to use with first-generation Mexican immigrants to Washington State. These experiences and skills with general and special populations will be utilized in the Transdisciplinary Research on Energetics and Cancer (TREC) Coordination Center as Dr. Neuhouser provides leadership to help develop commonalities in dietary assessment across the TREC Centers and leads the TREC CC dietary assessment activities.