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The Population-based Research to Optimize the Screening Process (PROSPR) is a National Institutes of Health (NIH)-funded initiative, currently in the second five-year funding cycle. During PROSPR I, the PROSPR Statistical Coordinating Center (SCC) led by PIs Drs. William Barlow and Mark Thornquist, established and operated a central data repository for pooled data (gathered by Research Centers) on the screened populations, the screening process, and clinical outcomes involving breast, cervical and colorectal cancers. The SCC provided analytical analyses for over 25 publications to date, along with being lead authors on approximately 10 papers.

PROSPR II, has three Research Centers, representing nine health systems, and one Coordinating Center. The PROSPR Coordinating Center (PCC), led by PIs Drs. Christopher Li, William Barlow, and Yingye Zheng, leads efforts on multi-level screening process factors, quality measures, data harmonization, and social determinants of health disparities involving cervical, lung and colorectal cancers. The Coordinating Center:

  • Leads efforts to optimize and standardize terminology, data collection, processing, and exchange across all three cancers, including quality control, management of pooled data, and oversight for the analysis and sharing of the data with investigators.
  • Provides logistical infrastructure for the PROSPR Research Centers and facilitates trans-PROSPR functions and activities, including maintaining the PROSPR secure website (PROSPR I), facilitating working group meeting and calls, hosting related webinars and organizing the semi-annual investigators meetings.